As I get older, I’m naturally (and selfishly) more invested in longevity, and doing everything I can to ensure my healthspan equals my lifespan – both of which I hope will be long!

Anti-aging and longevity have become the leading field of study for researchers, which makes perfect sense because aging is the only disease (and it is classed as a disease by the WHO) we will all be afflicted by.

In the quest for longevity and enhanced vitality, NMN (Nicotinamide Mononucleotide) has emerged as a promising supplement. From boosting energy levels to potentially extending lifespan, NMN is capturing the interest of health enthusiasts and researchers alike. This blog delves into what NMN is, how it works, and its potential benefits.

What is NMN?

Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3 (niacin) and a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme found in every cell of the body. NAD+ plays a vital role in various cellular processes, including energy metabolism, DNA repair, and gene expression regulation. As we age, NAD+ levels naturally decline, leading to a decrease in cellular function and an increase in age-related diseases.

How Does NMN Work?

NMN works by serving as a precursor to NAD+, meaning that once consumed, it is converted into NAD+ within the body. Here’s a simplified breakdown of the process:

1. Intake: NMN is taken orally as a supplement in powder or capsule form. Ideally, take in the morning with or without food.
2. Conversion: NMN is absorbed into the bloodstream and then converted into NAD+ in cells.
3. Utilization: The increased NAD+ levels support various cellular functions, enhancing energy production and promoting cellular repair. Studies show benefit at 250 mg to 1250 mg daily. I take 1 g daily and generally recommend 600mg – 1g for best results.

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Potential Benefits of NMN Supplementation

1. Improved Energy Metabolism: By boosting NAD+ levels, NMN enhances the function of mitochondria, the powerhouses of the cell, leading to improved energy production and reduced fatigue.

2. Enhanced Cognitive Function: Research suggests that NMN supplementation may support brain health by improving neuronal function and protecting against neurodegenerative diseases like Alzheimer's.

3. DNA Repair and Anti-Aging: NAD+ plays a crucial role in DNA repair mechanisms. Higher NAD+ levels can enhance the body’s ability to repair damaged DNA, potentially slowing the aging process and reducing the risk of age-related diseases.

4. Cardiovascular Health: NMN may improve heart function and promote blood vessel health by enhancing endothelial function, which is vital for maintaining blood flow and reducing the risk of cardiovascular diseases.

5. Improved Metabolic Function: NMN has been shown to enhance insulin sensitivity and support healthy metabolism, which can be beneficial in managing conditions like obesity and diabetes.

6. Physical Performance: By boosting mitochondrial function and energy production, NMN can enhance physical endurance and performance, making it a popular supplement among athletes.

While NMN is very well tolerated, one note of caution, when consuming NMN supplements, the conversion to NAD reduces levels of trimethylglycine/Betaine, a critical methyl donor. It’s important to replenish trimethylglycine levels, and Younited has you covered. We’ve added trimethylglycine to our NMN complex, as well as fortified it with D-Ribose, a critical component of ATP production.

In the ever-evolving landscape of health and wellness, NMN stands out as a beacon of hope for a healthier, more vibrant future. As research continues to unfold, we may unlock even more of its potential, bringing us closer to the dream of a longer, healthier life.

Sources and Further Reading

• Scientific Research Articles:

• Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 27(3), 513-528. This review discusses the biology and therapeutic potential of NMN and other NAD+ intermediates.
• Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. I. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism, 24(6), 795-806. This study highlights the potential anti-aging effects of NMN in animal models.

• Books:

• Sinclair, D. A., & LaPlante, M. D. (2019). Lifespan: Why We Age—and Why We Don’t Have To. Atria Books. This book by Dr. David Sinclair, a leading researcher in the field of aging, discusses the role of NAD+ and NMN in promoting longevity.

• Web Resources and Articles:

• Healthline (2020). What Is Nicotinamide Mononucleotide (NMN) and How Does It Work?  A comprehensive overview of NMN, including benefits and side effects.